Tuesday, March 10, 2015

CoQ10



CoQ10

Coenzyme Q10 is a fat-soluble compound primarily synthesized by the body and also consumed in the diet. Coenzyme Q10 is required for mitochondrial ATP synthesis and functions as an antioxidant in cell membranes. It also neutralizes free radicals directly.Tissue levels of coenzyme Q10 decline with age.

Lipid lowering medications inhibit a critical enzyme in both cholesterol and coenzyme Q10 biosynthesis also known as statins. These widely used cholesterol-lowering medications decrease the endogenous synthesis of coenzyme Q10. Therapeutic use of statins, including simvastatin (Zocor), pravastatin, lovastatin, rosuvastatin (Crestor), and atorvastatin (Lipitor), has been shown to decrease blood plasma or serum levels of coenzyme Q10. According to Mayo Clinic, people taking statins can experience side effects such as muscle pain, nausea and diarrhea, liver and kidney damage, and even increased blood sugar or type 2 diabetes. In a study published in the American Journal of Cardiology, researchers indicate that coenzyme Q10 seems to decrease muscle breakdown and reduce pain and discomfort on people taking statins.

Coenzyme Q10 supplementation has resulted in clinical and metabolic improvement in some patients with hereditary mitochondrial disorders.

Primary coenzyme Q10 deficiency is a rare. The resultant low tissue levels of coenzyme Q10 severely compromise neuronal and muscular function. Oral coenzyme Q10 supplementation has been shown to improve neurological and muscular symptoms in some patients with primary coenzyme Q10 deficiency. Decreased plasma levels of coenzyme Q10 have been observed in individuals with diabetes, cancer, and congestive heart failure.

Coenzyme Q10 is available without a prescription as a dietary supplement. Therapeutic doses for adults generally range from 100-300 mg/day, although doses as high as 3,000 mg/day have been used to treat early Parkinson's disease under medical supervision. Coenzyme Q10 is fat-soluble and is best absorbed with fat in a meal.

There have been no reports of significant adverse side effects of oral coenzyme Q10supplementation at doses as high as 1,200 mg/day. Although coenzyme Q10 supplements are relatively safe, they may decrease the anticoagulant efficacy of warfarin.

Patients taking statin medications should consider the use of a CoQ10 supplement to counteract this lack of production.
Dr Stephen Kelly is here at Family First Chiropractic on Monday to Friday and every other Saturday. Call to book. 403-347-3261 www.family1stchiro.ca. 142 Erickson Dr Red Deer.

Food
Serving
Coenzyme Q10 (mg)
Beef, fried 
3 ounces* 
2.6 
Herring, marinated 
3 ounces 
2.3 
Chicken, fried 
3 ounces 
1.4 
Soybean oil 
1 tablespoon 
1.3 
Canola oil 
1 tablespoon 
1.0 
Rainbow trout, steamed 
3 ounces 
0.9 
Peanuts, roasted 
1 ounce 
0.8 
Sesame seeds, roasted 
1 ounce 
0.7 
Pistachio nuts, roasted 
1 ounce 
0.6 
Broccoli, boiled 
1/2 cup, chopped 
0.5 
Cauliflower, boiled 
1/2 cup, chopped 
0.4 
Orange 
1 medium 
0.3 

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